WP 5

-Øsophagus funktion ved medfødt misdannelse

Main Objective. This project investigates 1) whether using cocultures of osteogenic cells and angiogenic factors with a composite can provide a live biomaterial; 2) if the composite can repair bone defect and enhance implant fixation in normal and osteoporotic sheep; and 3) in patients with osteoporosis via a randomized clinical trial.

Background

Osteoporosis is a common aging-related disorder manifested clinically by skeletal fractures. Osteoporotic fractures have a complex pathogenesis involving both trauma to the bone and increased skeletal fragility. One of the most important side effects of long-term glucocorticoid therapy is secondary osteoporosis. It is estimated that up to 50% of the patients chronically treated with glucocorticoids will suffer fractures. These fractures are often difficult to stabilize because of fixation failure in weak osteoporotic bone. Therefore, problems such as orthopaedic implant loosening, delayed healing or non-union have been major postoperative concerns. The repair of large bone defects remains a major clinical challenge, particularly in osteoporotic (OP) patients.

Approach

The investigations will be performed in this project are (Figure 1)

Research Interest

Combined delivery of osteogenic and angiogenic factors is a novel approach in bone regenerative engineering. This project is designed to investigate whether using co-cultures of MSCs and VEGF into a biomaterial composite provides a live bone graft substitute; and whether this composite can repair bone defect and enhance implant fixation when implanted in vivo in both normal and osteoporotic sheep. It may hold great promise in regenerative medicine with success of this project.

The resemblance between bones from sheep and humans provides an unique model giving an insight into the cellular processes and defect repairs of bone remodeling and formation, which would be impossible to investigate in other models for preclinical settings. Finally, a randomized clinical trial is the most important assessment for the efficacy of this



Available positions and Contacts

We always seek ambitious students (within medical or natural sciences) with a large degree of curiosity on nature’s biology. For questions, contact Niels Qvist (niels.qvist@rsyd.dk; +45 6541 3205).

Research group

Niels Qvist


Professor
CV 
Publications 


+ 45 65 41 32 05
niels.qvist@rsyd.dk

Research interest

Combined delivery of osteogenic and angiogenic factors is a novel approach in bone regenerative engineering. This project is designed to investigate whether using co-cultures of MSCs and VEGF into a biomaterial composite provides a live bone graft substitute; and whether this composite can repair bone defect and enhance implant fixation when implanted in vivo in both normal and osteoporotic sheep. It may hold great promise in regenerative medicine with success of this project.

The resemblance between bones from sheep and humans provides an unique model giving an insight into the cellular processes and defect repairs of bone remodeling and formation, which would be impossible to investigate in other models for preclinical settings. Finally, a randomized clinical trial is the most important assessment for the efficacy of this approach.

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Selected publications

Major Funding

 

Funding